The plot is based on the novel published by Garth Stein, which responds to the same name as the film. The story combines different feelings and situations committed to society such as pain, liberation, affection or risk. Enzo, a dog that has experienced many interesting adventures throughout his life, is the character that gives voice to the film. Despite not being a person of flesh and blood, this endearing animal will be able to give different lessons to human beings on what should be the appropriate way to act whatever the situation in which they are.