After losing his wife seven years ago, the eccentric Dr. John Dolittle, a reputed doctor and veterinarian, locked himself behind the walls of his mansion with the only company in his collection of exotic animals. But when the young queen falls seriously ill, Dolittle will have to leave, much to her regret, her life as a hermit to embark on an epic adventure to a mythical island in search of a cure, recovering her sense of humor and courage as intersects with old adversaries and while discovering wonderful creatures.